MYELOID NEOPLASIA Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3
نویسندگان
چکیده
1Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC; 2Institute of Biomedicine, Sahlgrenska University Hospital, Göteborg, Sweden; 3Department of Molecular Medicine, University of Malaya, Kuala Lumpur, Malaysia; 4School of Biological Sciences, Nanyang Technological University, Singapore, Republic of Singapore; and 5Department of Medicine, University of British Columbia, Vancouver, BC
منابع مشابه
Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3.
MEIS1 is a three-amino acid loop extension class homeodomain-containing homeobox (HOX) cofactor that plays key roles in normal hematopoiesis and leukemogenesis. Expression of Meis1 is rate-limiting in MLL-associated leukemias and potently interacts with Hox and NUP98-HOX genes in leukemic transformation to promote self-renewal and proliferation of hematopoietic progenitors. The oncogenicity of ...
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